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KMID : 1161420190220070685
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Journal of Medicinal Food
2019 Volume.22 No. 7 p.685 ~ p.695
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Aster glehni Extract Ameliorates Scopolamine-Induced Cognitive Impairment in Mice
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Liao Yulan
Bae Ho-Jung
Park Jong-Hun
Zhang Jiabao
Koo Bo-Kyung
Lim Mi-Kyung
Han Eun-Hye
Lee Sang-Ho
Jung Seo-Yun
Lew Jae-Hwan
Ryu Jong-Hoon
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Abstract
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The leaves of Aster glehni Fr. Schm. (Asteraceae) have been used to treat insomnia in Korea. Insomnia is a common adverse effect of therapeutic agents for Alzheimer's disease (AD), and the control of sleep disturbance may prevent dementia. We hypothesized that the leaves of A. glehni can attenuate cognitive dysfunctions observed in AD. We observed the ameliorating effects of the ethanolic extract of leaves of A. glehni (AG-D) on memory dysfunction through the Morris water maze test, the passive avoidance test, and the Y-maze test. We performed acetylcholinesterase (AChE) activity assay and Western blotting to determine the mechanism of action of AG-D. AG-D significantly attenuated memory dysfunction observed in the above behavior studies and inhibited the activity of AChE. AG-D also increased the levels of phosphorylation extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB), phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), and glycogen synthase kinase 3β (GSK-3β) and the expression levels of brain-derived neurotrophic factor (BDNF) in the hippocampi. These results suggest that AG-D ameliorates memory impairments by AChE inhibition and activation of ERK-CREB-BDNF and PI3K-Akt-GSK-3β signaling pathways. Taken together, this study suggests that AG-D could be used as a potential treatment for cognitive dysfunction.
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KEYWORD
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AChE inhibition, Aster glehni, behavioral tests, cognitive function, ERK-CREB-BDNF signaling pathway, PI3K-Akt-GSK-3β signaling pathway
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